INFORMATION FOR INVESTIGATORS

GPPAD Data Sharing Statement

Sharing anonymized data (data rendered anonymous in such a way that the data subject is not or no longer identifiable) within the scientific community is important for scientific progress that might eventually benefit patients. The Global Platform for Prevention of Autoimmune Diabetes (GPPAD) is committed to open data sharing in compliance with all applicable European and GPPAD Consortium Member State, Data Protection and Privacy Protection laws, rules and regulations.

GPPAD makes anonymized data of the type 1 diabetes risk screening (GPPAD-02) available to the scientific community on a regular basis. Data from over 40,000 individuals is currently available. An example built from synthetic data can be downloaded clicking the link below. For data request please send an email to cc@gppad.org indicating “GPPAD data sharing” in the subject.

Synthetic data

The available data includes:

  • Sex
  • FDR (First Degree Relative with type 1 diabetes)
  • HLA derived from SNPs rs17426593, rs2187668 and rs7454108
  • Genotyping results of the SNPs used in the calculation of the genetic risk score

 

HLA class II SNPs

RS NumberAllelesComments
rs17426593T:C
rs2187668
T:C
rs7454108
T:C
rs3129889
G:AProtective for T1D if G
rs1794265
-:CProtective for T1D if -

Other SNPs

RS NumberGeneAllelesMinor AlleleRisk Allele
rs1264813HLA A 24A:GAA
rs2395029HLA B 5701G:TGT
rs2476601PTPN22A:GAA
rs2816316RGS1G:TGT
rs3024505IL10C:TTC
rs1990760IFIH1A:GGA
rs3087243CTLA4A:GAG
rs10517086C4orf52A:GAA
rs2069763IL2G:TTT
rs6897932IL7RAC:TTC
rs3757247BACH2A:GAA
rs9388489C6orf173A:GGG
rs6920220TNFAIP3A:GAA
rs1738074TAGAPA:GAG
rs7804356SCAP2C:TCT
rs4948088COBLA:CAC
rs7020673GLIS3C:GCG
rs12722495IL2RAA:GGA
rs947474PRKCQA:GGA
rs10509540RNLS/C10orf59C:TCT
rs1004446INSC:TTC
rs4763879CD69A:GAA
rs2292239ERBB3G:TTT
rs3184504SH2B3C:TTT
rs1465788ZFP36L1A:GAG
rs17574546RASGRP1A:CCC
rs3825932CTSHC:TTC
rs12708716CLEC16AA:GGA
rs4788084IL27A:GAG
rs7202877CTRB2G:TGG
rs2290400ORMDL3C:TTC
rs7221109CCR7C:TTC
rs45450798PTPN2C:GCC
rs763361CD226C:TTT
rs425105PRKD2A:GGA
rs2281808SIRPGC:TTC
rs3788013UBASH3aA:CAA
rs5753037RPS3AP51C:TTT
rs229541IL2BC:TTT
rs5979785TLR8C:TCT
rs2664170GAB3A:GGG
rs917997IL18RAPT:CTC

GPPAD provides access to anonymized biobank material gathered from study participants to external investigators. One goal is to make all generated research available in the manner most conducive to furthering scientific research. Study participants’ privacy rights will always be respected.