Request for proposal (RFP)
ADVANCING THE UNDERSTANDING OF TYPE 1 DIABETES PATHOGENESIS (BIOSAMPLES PROVIDED FROM A PRIMARY PREVENTION TRIAL)
Launched in late 2017, the Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) is designed to carry out newborn screening in the general population, identify infants at high genetic risk of developing type 1 diabetes, and offer them participation in trials to prevent disease initiation.
The Primary Oral Insulin Trial (POInT), GPPAD’s first randomized controlled clinical trial, is designed to determine if administration of high dose oral insulin can prevent the initiation of type 1 diabetes-related autoimmunity in young children at high genetic risk. GPPAD completed enrollment of POInT in early 2021, with 1,050 participants enrolled, 94 of whom have developed type 1 diabetes-related autoantibodies. In addition to biosamples collected for trial purposes, an array of additional biosamples (serum, plasma, RNA, whole blood, PBMC, stool), which can be connected to relevant clinical data, are collected at multiple timepoints from 90% of POInT participants and biobanked.
We are now announcing a Request For Proposal (RFP) for investigators to perform innovative research on biosamples from the GPPAD POInT clinical trial utilizing cutting-edge analysis techniques relevant to pancreatic, metabolic or immune research, which complement ongoing research approaches and analyses being carried out by GPPAD.
For more information see this document Request For Proposal (RFP)
All information about the availability of samples and data can be found HERE
Direct scientific and application-related questions please contact GPPAD Central Office.
Request for applications to advance collaborative research in type 1 diabetes prevention
JDRF Australia and The Leona M. and Harry B. Helmsley Charitable Trust are requesting applications for new collaborations with the Environmental Determinants of Islet Autoimmunity (ENDIA) Study Group to answer important unknowns about type 1 diabetes mechanisms with the long-term aim of preventing the condition.
This RFA will provide access to the highly precious data and biosamples of ENDIA spanning pregnancy, birth, and early life, to successful applicants. Letters of Intent close 7 April 2023. Head to JDRF Australia’s website for more details or to apply.