GPPAD Study Group

Study Group

GPPAD-Coordinating Center (CC, 02)
Melanie Gündert, Stefanie Arnolds, Karina Blasius, Michaela Dilong, Nadine Friedl, Gertrud
Göppel, Florian Haupt, Luisa Hoffmann, Martin Heigermoser, Maja Hergl, Sandra Hummel, Manja Jolink, Krisztian Kisfügedi, Kristina Korhonova, Nadine Klein, Ramona Lickert Stefanie Löbner, Leonard Nevaril, Rebecca Niewöhner, Katharina Sarcletti, Marlon Scholz, Lena Schwenker, Katharina Schütte-Borkovec, Ricarda Stössel, Andreas Weiß, Christiane Winkler, José Maria Zapardiel Gonzalo, Lorena Müller
Belgium Clinical Center
Kristina Casteels, An Jacobs, Charlien Jannsen, Hilde Morobé, Jasmin Paulus, Anne Rochtus, Natalie Van den Driessche, Renka Van Heyste, Janne Houben, Veerle Vanhuyse, Brontë Vrancken
Germany, Dresden Clinical Center
Ezio Bonifacio, Reinhard Berner, Sari Arabi, Lisa Barbknecht, Uta Ceglarec, Sevina Dietz, Irena Drozd, Franziska Ehrlich, Gita Gemulla, Angela Hommel, Franziska Lange, Anja Loff, Peter Mirtschink, Anne Schille, Marc Weigelt, Pauline Wimberger, Nicole Zubizarreta
Germany, Hanover Clinical Center
Olga Kordonouri, Carolin Kruse, Sarah Landsberg, Karin Lange, Erika Marquardt, Mareike Niemeyer, Felix Reschke, Frank Roloff, Bianca Schmidt, Jantje Weiskorn, Thekla von dem Berge
Germany, Munich Clinical Center
Anette-Gabriele Ziegler, Peter Achenbach, Heidi Eifler, Annika Fehn, Anna Festl, Anna Hofelich, Stefanie Jacobson, Melina Kaiser, Claudia Matzke, Annette Munzinger, Franziska Reinmüller, Thaisa Rodrigues Tagliari, Katharina Sarcletti, Natalie Villalobos Trigueros, Merve Vurucu
Poland Clinical Center
Agnieszka Szypowska, Mariusz Ołtarzewski, Wiktoria Czerwińska, Adrianna Cieloch, Sylwia Dybkowska, Natalia Dziedzic, Elżbieta Górska, Lidia Groele, Agnieszka Mroczek, Dorota Owczarek, Katarzyna Popko, Beata Zduńczyk, Anna Zych
Sweden Clinical Center
Helena Elding Larsson, Markus Lundgren, Daniel Agardh, Sofie Alström Mortin, Rasmus Bennet,
Charlotte Brundin, Lina Fransson, Malin Goldman-Tsubarah, Maria Hyllengren, Ida Jönsson, Emma Karlsson, Marielle Lindström, Jessica Melin, Hannah Nenonen, Anita Ramelius, Kobra Rhamati, Falastin Salami, Hanna Samuelsson, Carina Törn
United Kingdom, Newcastle Clinical Center
Catherine Owen, Stephen Robson, Stephen Crulley, Marc Davies, Andrea Fenn, Helen Gallon, Fiona Jenkinson, Andrew Johnston, Sharon King, Caroline Miller, Fiona Yelnoorkar, Claire Wood

Acknowledgement

We thank participating families for their participation in type 1 diabetes research and for helping to develop therapies for prevention.
We also highly acknowledge the following support:
Data Safety and Monitoring Board:
Polly Bingley (University of Bristol, Bristol, UK), Ulrich Heininger (Division of Paediatric Infectious  Diseases and Vaccinology, University Children’s Hospital, Basel, Switzerland), Markus Pfirrmann (Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität, Munich, Germany), Wolfgang Rascher (Department of Pediatrics and Adolescent Medicine, Erlangen, Germany), Paul Turner (Nuffield Department of Medicine, Medical Science Division, Oxford, UK)
Beta-cell Autoantibody and Confirmatory Laboratory:
Institute of Diabetes Research, Helmholtz Munich, Neuherberg, Germany.
Bristol Medical School, The University of Bristol, Bristol, UK.
Genotyping Laboratory: 
Grace London, LGC Ltd., Hertfordshire, UK
Database/ Electronic Questionnaires: 
PHARMALOG, GmbH, Ismaning, Germany
Study Product Supply:
Infinant Health Davis, California, USA
Central Pharmacy:
Pharmacy of the University Hospital of Heidelberg, Germany
Biorepository:
Integrated BioBank of Luxembourg (IBBL), Dudelange, Luxembourg
IVRS:
GxP brain GmbH, Berlin, Germany

Study Group

GPPAD-Coordinating Center (CC; 02)
Melanie Gündert, Stefanie Arnolds, Karina Blasius, Michaela Dilong, Nadine Friedl, Gertrud
Göppel, Florian Haupt, Luisa Hoffmann, Martin Heigermoser, Maja Hergl, Sandra Hummel, Manja Jolink, Krisztian Kisfügedi, Kristina Korhonova, Nadine Klein, Ramona Lickert Stefanie Löbner, Leonard Nevaril, Rebecca Niewöhner, Katharina Sarcletti, Marlon Scholz, Lena Schwenker, Katharina Schütte-Borkovec, Ricarda Stössel, Andreas Weiß, Christiane Winkler, José Maria Zapardiel Gonzalo, Lorena Müller
Belgium Clinical Center
Kristina Casteels, An Jacobs, Charlien Jannsen, Hilde Morobé, Jasmin Paulus, Anne Rochtus, Natalie Van den Driessche, Renka Van Heyste, Janne Houben, Veerle Vanhuyse, Brontë Vrancken
Germany, Dresden Clinical Center
Ezio Bonifacio, Reinhard Berner, Sari Arabi, Lisa Barbknecht, Uta Ceglarec, Sevina Dietz, Irena Drozd, Franziska Ehrlich, Gita Gemulla, Angela Hommel, Franziska Lange, Anja Loff, Peter Mirtschink, Anne Schille, Marc Weigelt, Pauline Wimberger, Nicole Zubizarreta
Germany, Hanover Clinical Center
Olga Kordonouri, Carolin Kruse, Sarah Landsberg, Karin Lange, Erika Marquardt, Mareike Niemeyer, Felix Reschke, Frank Roloff, Bianca Schmidt, Jantje Weiskorn, Thekla von dem Berge
Germany, Munich Clinical Center
Anette-Gabriele Ziegler, Peter Achenbach, elanie Bunk, Anna Festl, Anna Hofelich, Stefanie Jacobson, Melina Kaiser, Alexandra Käßl, Claudia Matzke, Annette Munzinger, Samuel Owoeye, Thaisa Rodrigues Tagliari, Cigdem Sanverdi Katharina Sarcletti, Sarah Schill, Natalie Villalobos Trigueros, Merve Vurucu, Christiane Winkler
Sweden Clinical Center
Helena Elding Larsson, Markus Lundgren, Daniel Agardh, Sofie Alström Mortin, Rasmus Bennet,
Charlotte Brundin, Lina Fransson, Malin Goldman-Tsubarah, Maria Hyllengren, Ida Jönsson, Emma Karlsson, Marielle Lindström, Jessica Melin, Hannah Nenonen, Anita Ramelius, Kobra Rhamati, Falastin Salami, Hanna Samuelsson, Carina Törn
United Kingdom, Newcastle Clinical Center
Catherine Owen, Stephen Robson, Stephen Crulley, Marc Davies, Andrea Fenn, Helen Gallon, Fiona Jenkinson, Andrew Johnston, Sharon King, Caroline Miller, Fiona Yelnoorkar, Claire Wood
United Kingdom, Cambridge Clinical Center
Loredana Marcovecchio, Katarzyna Gajewska-Knapik, Elena Otero Romero, Suzannah Twiss, Ann-Marie Wardell

Acknowledgement

We thank participating families for their participation in type 1 diabetes research and for helping to develop therapies for prevention.
We also highly acknowledge the following support:
Data Safety and Monitoring Board:
Polly Bingley (University of Bristol, Bristol, UK), Ulrich Heininger (Division of Paediatric Infectious Diseases and Vaccinology, University Children’s Hospital, Basel, Switzerland), Markus Pfirrmann (Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität, Munich, Germany), Wolfgang Rascher (Department of Pediatrics and Adolescent Medicine, Erlangen, Germany), Paul Turner (Nuffield Department of Medicine, Medical Science Division, Oxford, UK)
Beta-Cell autoantibody laboratory:
Institute of Diabetes Research, Helmholtz Munich, Neuherberg, Germany
Central Laboratories:
– Institute of Diabetes Research, Helmholtz Munich, Neuherberg, Germany
– University Hospital Leipzig, Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
– Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
– King’s College London, London SE1 1UL, UK
– Thermo Fisher Scientific, Freiburg, Germany
Genotyping Laboratory:
Grace London, LGC Ltd., Hertfordshire, UK  
Electronic Questionnaires and Database:
PHARMALOG, GmbH, Ismaning, Germany  
Pharmacovigilance:
Dr. Nibler & Partner, Munich, Germany
IMP Supply:
Paul-Ehrlich-Institute (PEI), Institut: ZEPAI (Zentrum für Pandemie-Impfstoffe und Therapeutika), Langen, Germany
Study Pharmacy:
Pharmacy of the University Hospital of Heidelberg, Germany
Biorepository:
Integrated BioBank of Luxembourg (IBBL), Dudelange, Luxembourg

The GPPAD studies are supported by the Leona M. and Harry B. Helmsley Charitable Trust (Helmsley) grants #2018PG-T1D022 (The Global Platform for Prevention of Autoimmune Diabetes (GPPAD)-02 study and GPPAD coordinating center), #2110-04841 (GPPAD-02 study continuation), #2302-06623 (GPPAD-02 study continuation 2), #2003-04286 (GPPAD coordinating center continuation), #2018PG-T1D023 (GPPAD-03 study: POInT – Primary Oral Insulin Trial), #2018PG-T1D062 (Biobanking for the Primary Oral Insulin Trial)”, #2007-04031 (GPPAD-04 study: Supplementation with B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity (SINT1A)), #2302-06624 (GPPAD-05 study: Antiviral Action against Type 1 diabetes Autoimmunity (AVAnT1A)), #2103-05036 (GPPAD dried blood spot omics project), #2306-06064 (GPPAD Biosample RFP) and funding from Helmholtz Munich, German Research Center for Environmental Health, Germany, the Bavarian Ministry of Economic Affairs, Energy, and Technology (grant: Prevention of Autoimmune Diabetes–Digital Lab), the German Federal Ministry of Education and Research (BMBF) grant FKZ: 01KX1818 and EASD-Novo Nordisk Foundation Diabetes Prize for Excellence NNF22SA0081044 to the German Clinical Center Munich. Funding from the Swedish Diabetes Foundation to the Swedish site, Wellcome [107212/Z/15/Z], and JDRF [5-SRA-2015-130- A-N] to the UK Clinical Center Oxford, and the German Center for Diabetes Research (DZD e.V.) to the German Clinical Centers Munich and Dresden.

The authors AGZ, EB, and PA are inventors of a patent entitled “Method for determining the risk to develop type1 diabetes” (WO 2019/002364).